Neuropoietin Principle in Gastric Secretion

of a specific reaction, which in the normal person takes place as a result of the presence in the stomach of a specific factor in the food (extrinsic) and a factor in the gastric juice (intrinsic) (Castle, 1929; Castle et al., 1931). In pernicious ansemia, disturbances of the gastro-intestinal tract and of the central nervous system are associated. Neural (Smithburn and Zerfas, 1931; Goldhamer et al., 1934; Baker et al., 1932; Strauss et al., 1935) and sometimes mental symptoms (Lurie, 1919; McAlpine, 1929) may appear long before the development of per* nicious anaemia (Greenfield and O'Flynn, 1933)Ahrens (1932) has stated that early cases of pernicious anaemia would probably at some time show evidence of sub-acute combined degeneration of the cord. The neurological signs (Wood) 1925; Baumgartner and Smith, 1927; Hance, 1930) and degenerative changes in the spinal cord (Reed and Wyckoff, 1926), in cases of pellagra and in sprue resembling those in pernicious anaemia, have been observed. The gastric atrophy and secretory failure classical in pernicious anaemia occur also less frequently in pellagra (Denton, 1928; Lynch, 1930), and in sprue (Mackie and Fairley, 1929; Castle et al., 1935). Tke observations of Minot and Murphy (1927), Colm and his associates (1928), Ungley and Suzman (1929), Strauss and Castle (1932) and of others